smtp relay

Assuming you're installing the yum version of Exim on a CentOS server, you'll need to make two configuration changes. The first is to allow the IP of the mailserver to relay through the smarthost. Open the configuration at /etc/exim/exim.conf, find the line referenced below and edit it by adding the relay server IP 109.201.130.65 at the end as shown below.

add this in server from where your mail will exit

hostlist   relay_from_hosts = 127.0.0.1

eg: hostlist   relay_from_hosts = 127.0.0.1 : 109.201.130.65

domainlist relay_domains = lsearch;/etc/virtual/domains

add domain in the aboe file also

in vetacp

hostlist relay_from_hosts = 127.0.0.1 : 43.225.53.162

these settings needs to be done on mail server from where mail will realy to another server

We might need to make changes on the SPF record. Replace the current server IP address and add the relay IP.
eg: v=spf1 a mx ip4:109.201.130.65 ~all

Step 3: Configure the MTA

On the same page Exim Configuration Editor, click on the Advanced Editor button and search on the page for “Section: POSTMAILCOUNT” and add the below details:

smart_route:
driver = manualroute
domains = ! +local_domains
ignore_target_hosts = 127.0.0.0/8
transport = remote_smtp
route_list = * smtprelay.snel.com::587
no_more

If the “Section: POSTMAILCOUNT” is not available then proceed to next step 4, or else proceed to step 5.

Step 4: IF “Section: POSTMAILCOUNT” is not available

On the Exim Configuration Editor page search for “Section: ROUTERSTART” and add below settings:

smart_route:
driver = manualroute
domains = ! +local_domains
ignore_target_hosts = 127.0.0.0/8
transport = remote_smtp
route_list = * smtprelay.snel.com::587
no_more